Cafergot


Cafergot

     * Generic Name: ergotamine tartrate and caffeine
     * Brand Name: Cafergot


     * What is caffeine and ergotamine?
     * What are the possible side effects of caffeine and ergotamine?
     * What is the most important information I should know about
       caffeine and ergotamine?
     * What should I discuss with my healthcare provider before using
       caffeine and ergotamine ?
     * How should I use caffeine and ergotamine?
     * What happens if I miss a dose?
     * What happens if I overdose?
     * What should I avoid while using caffeine and ergotamine?
     * What other drugs will affect caffeine and ergotamine?
     * Where can I get more information?

What is caffeine and ergotamine?

   Caffeine is a stimulant that causes narrowing of blood vessels
   (vasoconstriction).

   Ergotamine is in a group of drugs called ergot alkaloids
   (ER-got AL-ka-loids). It works by narrowing the blood vessels
   around the brain. Ergotamine also affects blood flow patterns that are
   associated with certain types of headaches.

   Caffeine and ergotamine is a combination medicine used to treat or
   prevent a migraine type headache.

   This medication will only treat a headache that has already begun. It
   will not prevent migraine headaches or reduce the number of attacks.

   Caffeine and ergotamine should not be used to treat common tension
   headaches or any headache that seems to be different from your usual
   migraine headaches.

   Caffeine and ergotamine may also be used for purposes not listed in
   this medication guide.

What are the possible side effects of caffeine and ergotamine?

   Get emergency medical help if you have any of these signs of an
   allergic reaction: hives; difficulty breathing; swelling of your face,
   lips, tongue, or throat.

   Stop using caffeine and ergotamine and call your doctor at once if you
   have:
     * weak pulses in your arms and legs, numbness and tingling or pain in
       your hands or feet, blue-colored fingers or toes;
     * painful sores on your rectum after using the rectal
       suppositories;
     * sudden numbness or weakness (especially on one side of the
       body), sudden severe headache, slurred speech, problems with vision
       or balance;
     * fast or slow heart rate;
     * leg weakness, muscle pain in your arms or legs;
     * severe pain in your stomach or lower back;
     * little or no urinating;
     * chest discomfort, dry cough or hack, feeling short of breath on
       exertion; or
     * dangerously high blood pressure (severe headache, blurred
       vision, buzzing in your ears, anxiety, confusion, chest pain,
       shortness of breath, uneven heartbeats, seizure).

   Common side effects may include:
     * dizziness, spinning sensation;
     * weakness;
     * nausea, vomiting; or
     * mild itching or swelling.

   This is not a complete list of side effects and others may occur. Call
   your doctor for medical advice about side effects. You may report side
   effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about caffeine and
ergotamine?

   This medication can harm an unborn baby or cause birth defects. Do
   not use if you are pregnant.

   You should not use caffeine and ergotamine if you have coronary
   heart disease, high blood pressure, circulation problems, liver
   or kidney disease, or a serious infection called sepsis.

   Some medicines can cause a dangerous decrease in blood flow when used
   with caffeine and ergotamine. A severe decrease in blood flow to the
   brain and other parts of the body can lead to dangerous side effects.

   Tell your doctor about all medicines you use, and those you start or
   stop using, especially: atazanavir, boceprevir, clarithromycin,
   delavirdine, fosamprenavir, imatinib, indinavir, isoniazid,
   itraconazole, ketoconazole, nefazodone, nelfinavir, nicardipine,
   posaconazole, quinidine, ritonavir, saquinavir, telaprevir,
   telithromycin, or voriconazole.

   Cafergot Patient Information including How Should I Take
   Migraine Headaches:Symptoms, Triggers and Treatment

   A Visual Guide to Migraine Headaches Slideshow
   Headaches & Migraines: Surprising Headache & Migraine Triggers

   Headache and Migraine Triggers Slideshow
   RxList

   Take the Headaches Quiz

What should I discuss with my healthcare provider before using caffeine and
ergotamine ?

   You should not use this medicine if you are allergic to caffeine or
   ergotamine, if you are pregnant, or if you have:
     * coronary heart disease;
     * high blood pressure;
     * blood circulation problems;
     * liver disease;
     * kidney disease; or
     * a serious infection called sepsis.

   Some medicines can cause a dangerous decrease in blood flow when used
   with caffeine and ergotamine. A severe decrease in blood flow to the
   brain and other parts of the body can lead to dangerous side effects.
   Your doctor may need to change your treatment plan if you use any of
   the following drugs:
     * imatinib;
     * isoniazid;
     * nefazodone;
     * an antibiotic--clarithromycin, telithromycin;
     * antifungal medication--itraconazole, ketoconazole,
       posaconazole, voriconazole;
     * heart medication--nicardipine, quinidine;
     * hepatitis C medications--boceprevir, telaprevir; or
     * HIV/AIDS medication--atazanavir, delavirdine,
       fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.

   FDA pregnancy category X. This medication can harm an unborn baby or
   cause birth defects. Do not use caffeine and ergotamine if you are
   pregnant. Tell your doctor right away if you become pregnant during
   treatment. Use effective birth control while you are using this
   medication.

   Caffeine and ergotamine can pass into breast milk and may harm a
   nursing baby. You should not breast-feed while using this medicine.

How should I use caffeine and ergotamine?

   Follow all directions on your prescription label. Never use more than
   your recommended dose. Overuse of migraine headache medicine can
   make headaches worse. Tell your doctor if the medicine seems to stop
   working as well in treating your migraine attacks. This medicine is not
   for daily use.

   To use caffeine and ergotamine tablets:
     * Take 2 tablets of caffeine and ergotamine as soon as you notice
       headache symptoms, or after an attack has already begun.
     * If your headache does not completely go away, you may take 1 more
       tablet after at least 30 minutes have passed.
     * If additional medication is needed, you may take 1 tablet every 30
       minutes up to a total of 6 tablets for one migraine attack.

   If you still have migraine symptoms after taking a total of 6 tablets,
   call your doctor. Do not take more than a total of 6 tablets in any
   24-hour period. Do not take more than a total of 10 tablets over a
   period of 7 days.

   Do not take a rectal suppository by mouth. It is for use only in your
   rectum.

   Wash your hands before and after inserting the rectal suppository.

   To use caffeine and ergotamine rectal suppositories:
     * Insert 1 suppository at the first sign of migraine headache
       symptoms, or after an attack has already begun.
     * Remove the wrapper before inserting the suppository. Avoid handling
       the suppository too long or it will melt in your hands.
     * Lie on your back with your knees up toward your chest. Gently
       insert the suppository into your rectum about 1 inch.
     * For best results, stay lying down for a few minutes. The
       suppository will melt quickly and you should feel little or no
       discomfort while holding it in. Avoid using the bathroom just after
       using the suppository.
     * If your headache does not completely go away, use 1 more
       suppository after at least 1 hour has passed.

   If you still have migraine symptoms after using a total of 2 rectal
   suppositories, call your doctor. Do not use more than a total of 2
   suppositories per headache. Do not use more than a total of 5
   suppositories over a period of 7 days.

   Do not share this medication with another person, even if they have the
   same symptoms you have.

   Store at room temperature away from moisture and heat.

   Cafergot Patient Information including If I Miss a Dose
   Migraine Headaches:Symptoms, Triggers and Treatment

   A Visual Guide to Migraine Headaches Slideshow
   Headaches & Migraines: Surprising Headache & Migraine Triggers

   Headache and Migraine Triggers Slideshow
   RxList

   Take the Headaches Quiz

What happens if I miss a dose?

   Since caffeine and ergotamine is used only when needed, you are not
   likely to miss a dose.

   Do not take more than 6 caffeine and ergotamine tablets per day or more
   than 10 tablets per week.

   Do not use more than 2 suppositories per headache or 5 suppositories
   per week.

What happens if I overdose?

   Seek emergency medical attention if you think you have used too much of
   this medicine. An overdose of caffeine and ergotamine can be fatal.

What should I avoid while using caffeine and ergotamine?

   Do not use caffeine and ergotamine within 24 hours before or after
   using another migraine headache medicine, including:
     * dihydroergotamine, ergonovine, or methylergonovine; or
     * almotriptan, eletriptan, frovatriptan, naratriptan,
       sumatriptan, rizatriptan, or zolmitriptan.

   Grapefruit and grapefruit juice may interact with caffeine and
   ergotamine and lead to unwanted side effects. Avoid the use of
   grapefruit products while taking caffeine and ergotamine.

What other drugs will affect caffeine and ergotamine?

   Tell your doctor about all medicines you use, and those you start or
   stop using during your treatment with caffeine and ergotamine,
   especially:
     * aprepitant;
     * cimetidine;
     * cyclosporine;
     * haloperidol;
     * imatinib;
     * nicotine;
     * an antibiotic--ciprofloxacin, doxycycline,
       erythromycin, metronidazole, norfloxacin, tetracycline;
     * antifungal medication--clotrimazole, fluconazole,
       voriconazole;
     * an antidepressant--desipramine, fluoxetine,
       fluvoxamine, sertraline;
     * diet pills, stimulants, or ADHD medication;
     * heart or blood pressure medication--amiodarone, diltiazem,
       dronedarone, lidocaine, propranolol, verapamil;
     * HIV/AIDS medication--atazanavir, fosamprenavir, efavirenz,
       darunavir when given with ritonavir, saquinavir; or
     * medicines to treat asthma, colds or allergies.

   This list is not complete. Other drugs may interact with caffeine and
   ergotamine, including prescription and over-the-counter medicines,
   vitamins, and herbal products. Not all possible interactions are listed
   in this medication guide.

Where can I get more information?

   Your pharmacist can provide more information about caffeine and
   ergotamine.
     __________________________________________________________________

   Remember, keep this and all other medicines out of the reach of
   children, never share your medicines with others, and use this
   medication only for the indication prescribed.
   Every effort has been made to ensure that the information provided by
   Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
   but no guarantee is made to that effect. Drug information contained
   herein may be time sensitive. Multum information has been compiled for
   use by healthcare practitioners and consumers in the United States and
   therefore Multum does not warrant that uses outside of the United
   States are appropriate, unless specifically indicated otherwise.
   Multum's drug information does not endorse drugs, diagnose patients or
   recommend therapy. Multum's drug information is an informational
   resource designed to assist licensed healthcare practitioners in caring
   for their patients and/or to serve consumers viewing this service as a
   supplement to, and not a substitute for, the expertise, skill,
   knowledge and judgment of healthcare practitioners. The absence of a
   warning for a given drug or drug combination in no way should be
   construed to indicate that the drug or drug combination is safe,
   effective or appropriate for any given patient. Multum does not assume
   any responsibility for any aspect of healthcare administered with the
   aid of information Multum provides. The information contained herein is
   not intended to cover all possible uses, directions, precautions,
   warnings, drug interactions, allergic reactions, or adverse effects. If
   you have questions about the drugs you are taking, check with your
   doctor, nurse or pharmacist.

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