Fosamax

Fosamax

     * Generic Name: alendronate sodium
     * Brand Name: Fosamax


     * What is alendronate (Binosto, Fosamax)?
     * What are the possible side effects of alendronate (Binosto,
       Fosamax)?
     * What is the most important information I should know about
       alendronate (Binosto, Fosamax)?
     * What should I discuss with my healthcare provider before taking
       alendronate (Binosto, Fosamax)?
     * How should I take alendronate (Binosto, Fosamax)?
     * What happens if I miss a dose (Binosto, Fosamax)?
     * What happens if I overdose (Binosto, Fosamax)?
     * What should I avoid while taking alendronate (Binosto,
       Fosamax)?
     * What other drugs will affect alendronate (Binosto, Fosamax)?
     * Where can I get more information (Binosto, Fosamax)?

What is alendronate (Binosto, Fosamax)?

   Alendronate is a bisphosphonate (bis FOS fo nayt) medicine that
   alters bone formation and breakdown in the body. This can slow bone
   loss and may help prevent bone fractures.

   Alendronate is used to treat osteoporosis caused by menopause,
   steroid use, or gonadal failure. This medicine is for use when you
   have a high risk of bone fracture due to osteoporosis.

   Alendronate is also used to treat Paget's disease of bone.

   Alendronate may also be used for purposes not listed in this medication
   guide.

What are the possible side effects of alendronate (Binosto, Fosamax)?

   Get emergency medical help if you have signs of an allergic reaction:
   hives; wheezing, difficulty breathing; swelling of your face, lips,
   tongue, or throat.

   Stop using alendronate and call your doctor at once if you have:
     * chest pain, new or worsening heartburn;
     * difficulty or pain when swallowing;
     * pain or burning under the ribs or in the back;
     * severe heartburn, burning pain in your upper stomach, or
       coughing up blood;
     * new or unusual pain in your thigh or hip;
     * jaw pain, numbness, or swelling;
     * severe joint, bone, or muscle pain; or
     * low calcium levels--muscle spasms or contractions, numbness or
       tingly feeling (around your mouth, or in your fingers and toes).

   Common side effects may include:
     * heartburn, upset stomach;
     * stomach pain, nausea;
     * diarrhea, constipation; or
     * bone pain, muscle or joint pain.

   This is not a complete list of side effects and others may occur. Call
   your doctor for medical advice about side effects. You may report side
   effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about alendronate
(Binosto, Fosamax)?

   You should not take alendronate if you have problems with your
   esophagus, or low levels of calcium in your blood.

   Do not take alendronate if you cannot sit upright or stand for at least
   30 minutes after taking the medicine.

   Alendronate can cause serious problems in the stomach or esophagus.
   Stop using alendronate and call your doctor at once if you have chest
   pain, new or worsening heartburn, or pain when swallowing.

   Also call your doctor if you have muscle spasms, numbness or tingling
   (in hands and feet or around the mouth), new or unusual hip pain,
   or severe pain in your joints, bones, or muscles.



What should I discuss with my healthcare provider before taking alendronate
(Binosto, Fosamax)?

   You should not take alendronate if you are allergic to it, or if you
   have:
     * low levels of calcium in your blood (hypocalcemia); or
     * problems with the muscles in your esophagus (the tube that connects
       your mouth and stomach).

   Do not take alendronate if you cannot sit upright or stand for at least
   30 minutes. Alendronate can cause serious problems in the stomach or
   esophagus. You must stay upright for at least 30 minutes after taking
   this medicine.

   To make sure alendronate is safe for you, tell your doctor if you have
   ever had:
     * trouble swallowing;
     * problems with your stomach or digestion;
     * hypocalcemia;
     * a dental problem (you may need a dental exam before you begin
       taking alendronate);
     * kidney disease; or
     * any condition that makes it hard for your body to absorb
       nutrients from food (malabsorption).

   The effervescent tablet contains a lot of sodium. Tell your doctor if
   you are on a low-salt diet before using this form of alendronate.

   In rare cases, this medicine may cause bone loss (osteonecrosis) in the
   jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose
   teeth, or slow healing after dental work. The longer you use
   alendronate, the more likely you are to develop this condition.

   Osteonecrosis of the jaw may be more likely if you have cancer or
   received chemotherapy, radiation, or steroids. Other risk
   factors include blood clotting disorders, anemia (low red blood
   cells), and a pre existing dental problem.

   Talk with your doctor about the risks and benefits of using this
   medication.

   It is not known whether this medicine will harm an unborn baby. Tell
   your doctor if you are pregnant or plan to become pregnant.

   It is not known whether alendronate passes into breast milk or if it
   could harm a nursing baby. Tell your doctor if you are breast-feeding a
   baby.

How should I take alendronate (Binosto, Fosamax)?

   Alendronate is taken either once daily or once per week. Follow all
   directions on your prescription label. Do not take this medicine in
   larger or smaller amounts or for longer than recommended.

   Take alendronate first thing in the morning, at least 30 minutes before
   you eat or drink anything or take any other medicine. If you take
   alendronate only once per week, take it on the same day each week and
   always first thing in the morning.

   Take with a full glass (6 to 8 ounces) of plain water. Do not use
   coffee, tea, soda, juice, or mineral water. Do not eat or drink
   anything other than plain water.

   Measure liquid medicine with the dosing syringe provided, or with a
   special dose-measuring spoon or medicine cup. If you do not have a
   dose-measuring device, ask your pharmacist for one.

   Do not crush, chew, or suck on an alendronate regular tablet. Swallow
   it whole.

   Dissolve the effervescent tablet in at least 4 ounces of water (at room
   temperature, not hot or cold). Let the tablet dissolve for 5 minutes.
   Stir this mixture for 10 seconds and drink all of it right away. Add a
   little more water to the glass, swirl gently and drink right away.

   For at least 30 minutes after taking alendronate:
     * Do not lie down or recline.
     * Do not take any other medicine including vitamins, calcium, or
       antacids.

   Pay special attention to your dental hygiene while taking alendronate.
   Brush and floss your teeth regularly. If you need to have any dental
   work (especially surgery), tell the dentist ahead of time that you are
   using alendronate.

   Alendronate is only part of a complete program of treatment that may
   also include diet changes, exercise, bone mineral density
   testing, and taking calcium and vitamin supplements. Follow your
   doctor's instructions very closely.

   Store at room temperature away from moisture and heat. Keep unused
   effervescent tablets in the foil blister pack.

   Your doctor will determine how long to treat you with this medicine.
   Alendronate is often given for only 3 to 5 years.



What happens if I miss a dose (Binosto, Fosamax)?

   Once-daily dosing: If you forget to take alendronate first thing in the
   morning, do not take it later in the day. Wait until the following
   morning and skip the missed dose. Do not take two (2) doses in one day.

   Once-per-week dosing: If you forget to take alendronate on your
   scheduled day, take it first thing in the morning on the day after you
   remember the missed dose. Then return to your regular weekly schedule
   on your chosen dose day. Do not take 2 doses in one day.

What happens if I overdose (Binosto, Fosamax)?

   Drink a full glass of milk and seek emergency medical attention or call
   the Poison Help line at 1-800-222-1222. Do not make yourself vomit and
   do not lie down.

What should I avoid while taking alendronate (Binosto, Fosamax)?

   Avoid taking any other medicines for at least 30 minutes after taking
   alendronate. This includes vitamins, calcium, and antacids. Some
   medicines can make it harder for your body to absorb alendronate.

   Avoid smoking, or try to quit. Smoking can reduce your bone mineral
   density, making fractures more likely.

   Avoid drinking large amounts of alcohol. Heavy drinking can also cause
   bone loss.

What other drugs will affect alendronate (Binosto, Fosamax)?

   Tell your doctor about all your current medicines and any you start or
   stop using, especially:
     * aspirin; or
     * NSAIDs (nonsteroidal anti-inflammatory drugs)--ibuprofen (Advil,
       Motrin), naproxen (Aleve), celecoxib, diclofenac,
       indomethacin, meloxicam, and others.

   This list is not complete. Other drugs may interact with alendronate,
   including prescription and over-the-counter medicines, vitamins, and
   herbal products. Not all possible interactions are listed in this
   medication guide. Talk with your doctor about the best dosing schedule
   for your other medicines.

Where can I get more information (Binosto, Fosamax)?

   Your pharmacist can provide more information about alendronate.

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